Databases & Searches
The National Toxicology Program makes available data from more than 500 two-year, two species, toxicology and carcinogenesis studies collected by the NTP and its predecessor, the National Cancer Institute's Carcinogenesis Testing Program, are stored in a database at NIEHS. The NTP database also contains the results collected on approximately 300 toxicity studies from shorter duration tests and from genetic toxicity studies, which includes both in vitro and in vivo tests. In addition, test data from the immunotoxicity, developmental toxicity and reproductive toxicity studies are continually being added to this database.
The Chemical Effects in Biological Systems (CEBS) database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial and governmental laboratories. CEBS is designed to display data in the context of biology and study design, and to permit data integration across studies for novel meta analysis. Read this brochure for an overview of CEBS.
DrugMatrix and ToxFx Databases
DrugMatrix is the scientific communities' largest molecular toxicology reference database and informatics system. DrugMatrix is populated with the comprehensive results of thousands of highly controlled and standardized toxicological experiments in which rats or primary rat hepatocytes were systematically treated with therapeutic, industrial, and environmental chemicals at both non-toxic and toxic doses. Following administration of these compounds in vivo, comprehensive studies of the effects of these compounds were carried out at multiple time points and in multiple target organs.
ToxFx is an automated toxicogenomics analysis application. The ToxFX analytical approach utilizes toxicogenomic signatures, specially-curated biochemical pathways and other relevant data to interpret toxicity-related transcriptomic data in minutes and presents the results as a detailed, customized report. This report is intended to improve your understanding of compound toxicity.
Read this brochure for an overview of Drug Matrix and ToxFx.
Atlas of Mouse Liver Lesions
The Atlas provides digitized images of mouse liver lesions. Pathologists and others can view the images to familiarize themselves with the spontaneous and chemically induced lesions seen in the livers of B6C3F1 mice.
Nonneoplastic Lesion Atlas
The Nonneoplastic Lesion Atlas is a database for non-neoplastic lesions that are organized by organ system and employs a set of guidelines developed for consistent terminology.
NICEATM LLNA Database
On behalf of ICCVAM, NICEATM has conducted a number of analyses to evaluate the usefulness of the murine local lymph node assay (LLNA) to identify potential skin sensitizers. NICEATM is making this data available for reference to interested stakeholders for developing and evaluating alternative methods that replace, reduce, or refine the use of animals for skin sensitization testing.
- The Excel spreadsheet contains three pages: (1) data, (2) references, and (3) abbreviations.
- The database includes data published through 2010.
- These data have been extracted from published and unpublished data sources with permission. Users of this database should consult the original data source for questions regarding data quality and/or authenticity.
Database users please note:
Two non-study data searches are available. Search the NTP website by entering a search term in the upper right-hand corner of this page and clicking "Search."
A search of items nominated to be studied is available by clicking here.